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pentobarbital will reduce the extent or effect of elbasvir/grazoprevir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. The therapeutic effect of elbasvir/grazoprevir could be decreased if coadministered with sturdy CYP3A inducers and it is therefore contraindicated.pentobarbital will reduce the extent or effect of doxorub